Mitopure Reaches Milestone: 25th Human Clinical Trial

A Milestone in Longevity: Launching Our 25th Human Clinical Study on Mitopure (Urolithin A)

For more than 15 years, Timeline has been redefining what a supplement company can and should be. Unlike much of the industry, we lead with high-quality, clinically validated science before a product ever reaches the market. Every Timeline product begins in the lab, undergoing rigorous preclinical testing, followed by gold-standard human clinical trials—many of which are published in the world’s most highly regarded medical journals.

While this level of scientific integrity is woven into the fabric of our company, it is far from the norm in the supplement space. It’s also what makes our latest achievement especially meaningful.

Timeline has just launched our 25th human clinical study on Mitopure, marking a new milestone in our mission to bring evidence-based longevity solutions to the world.

Why Urolithin A—and Why Mitopure™

Urolithin A is a postbiotic compound produced in the gut from ellagitannins found in foods like pomegranates. What makes it remarkable is its ability to stimulate mitophagy—the process by which cells recycle damaged mitochondria. This cellular cleanup is essential for maintaining energy, muscle function, and resilience as we age.

At Timeline, we’ve developed Mitopure™, our proprietary, ultra-pure form of Urolithin A. It is the only Urolithin A to be designated as FDA GRAS (Generally Recognized As Safe) and the only form that has been clinically studied in humans. Mitopure is the foundation of our research and product innovation, and it powers our commitment to evidence-based healthy aging.

Over the past decade, our clinical research has shown that Mitopure can:

• Improve mitochondrial health ^[1]
• Support cellular energy production ^[2]
• Enhance muscle strength^[3]
• Improve skin wrinkling and hydration when applied topically^[4]
• Reduce inflammaging and immune fatigue

A Diverse and Inclusive Research Journey

Across our 25 clinical studies, we’ve enrolled over 2,200 participants, with two-thirds being women—a reflection of our commitment to inclusive science. Our participants have spanned individuals 18 years old to those in the 9th decade of life, individuals competing in the Olympics to individuals with obesity and physical limitations, and even an inspiring 89-year-old woman ecstatic about her improved ability to garden. The broad relevance and safety of Mitopure are vast and only expanding across the aging spectrum.

This diversity has allowed us to explore how Mitopure supports cellular health in different lifestyles, age groups, and physiological conditions—bringing us closer to personalized and targeted longevity solutions.

Spotlight on the 25th Study: Brain Longevity

Our latest clinical study marks a new frontier: brain health and longevity. As people live longer, maintaining cognitive function has become one of the most pressing frontiers in healthy aging. Mitochondria — described as the “powerhouses” of our cells — supply the energy brain cells need to function at their best. Research suggests that supporting mitochondrial health may play an important role in sustaining brain performance and resilience over time.^[5]

Studies with Urolithin A in animal models have shown promising effects on brain health. Now, we’re entering the next chapter—testing whether Mitopure may support healthy brain aging in humans.

With 650 participants, it will be the largest clinical study ever conducted on Mitopure to date . The trial is designed to explore whether a novel supplement containing Mitopure can support key aspects of brain health, including cognitive performance, energy levels, and sleep quality.

ClinicalTrials.gov Identifier: NCT07060898

We’re excited to explore how brain health can be enhanced through targeted nutrition and what this means for long-term cognitive resilience.

A Commitment to Scientific Rigor

At Timeline, we don’t just believe in the power of Mitopure —we prove it through peer-reviewed research, clinical validation, and transparency. Our studies are conducted in collaboration with leading academic institutions and follow the highest standards of clinical science: placebo-controlled, randomized, double-blind clinical trials.

Looking Ahead

This milestone is more than a number—it’s a testament to the dedication of our research team, the trust of our study participants, and the growing global interest in evidence-based longevity solutions. As we continue to unlock the potential of cellular health, we remain committed to translating science into meaningful outcomes for people everywhere.

Thank you for being part of this journey.