What is a Urolithin A supplement used for?

Urolithin A is a postbiotic nutrient that can be used to increase energy, improve strength and endurance, and promote healthy aging.

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In the quest for optimal health and longevity, an exciting new player has emerged on the supplement scene: Urolithin A. This naturally occurring compound is gaining recognition based on incredible scientific evidence.

If you’ve only just recently heard of Urolithin A, this blog is for you. We’ll dive into the scientific studies, explaining what a Urolithin A supplement is used for and uncover why it's becoming the foundational supplement for those seeking to target healthy aging and longevity.

What is Urolithin A

What is Urolithin A?

Simply put, Urolithin A is a natural molecule derived from plant compounds called polyphenols. It triggers a crucial cellular renewal process, ensuring that your cells have more energy. This compound is not directly available to us from food. Instead, we need a healthy gut microbiome to create it for us. Unfortunately, the ability to produce Urolithin A varies significantly among individuals, and even for those of us who can make it, we might not be able to make much of it.[1]

Urolithin A has drawn scientific interest due to its potential to enhance mitochondrial function — the powerhouses of our cells. Mitochondria are responsible for producing energy and play a crucial role in overall health and aging.

The unique action of Urolithin A lies in its ability to stimulate mitophagy, a process that helps in the renewal of mitochondria by removing the damaged ones.

What is a Urolithin A supplement used for?

Based on its ability to target mitochondrial health, people are using Urolithin A supplements for several benefits.

  • Cellular energy: By stimulating the renewal of our mitochondria, our cells are better able to generate more energy.[2] More energy for your cells means more energy for you to perform your best.
  • Healthy aging: Declining mitochondrial function and declining levels of mitophagy are key hallmarks of why we age. A Urolithin A supplement directly targets the way cells age to promote healthy aging.
  • Muscle strength and endurance: We know that muscle health starts to decline in our 30s. [3]Whether you are an Olympic athlete, a couch potato, or somewhere in between, your muscles use tons of energy made by your mitochondria, and the science is clear - Urolithin A supplements can improve[4] muscle strength and endurance.[5]
  • Skin health: Topical application of Urolithin A targets both the intrinsic (internal) and extrinsic (external) factors that age the skin. Studies have shown that Mitopure used on the skin results in healthier, more resilient, youthful-looking skin.[6]
Where does Urolithin A Come From?

Only 40% of humans are capable of naturally Producing Urolithin A

Where does Urolithin A come from?

Urolithin A is not directly found in the food we eat. Instead, our gut microbiome converts polyphenols from some of the foods we eat (like pomegranates) into Urolithin A. The problem is that most of us don’t have the right gut microbiome to make Urolithin A. And even for the few people who do have the right gut microbiome, chances are you aren’t making enough of it.[7]

That’s where a Urolithin A supplement like Mitopure® comes in. Mitopure is the first and only clinically validated Urolithin A supplement, providing six times more Urolithin A than diet alone.

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Understanding the limitations of natural Urolithin A production in our bodies highlights the value of a supplement like Mitopure®. By providing a direct and potent source of Urolithin A, Mitopure® ensures that individuals can reap the benefits of this powerful compound, regardless of their gut microbiome's composition.

Wrapping up

Mitopure (Urolithin A) stands out as a supplement with the potential to revolutionize how we approach health and aging. Its targeted action on mitochondrial health addresses key aspects of cellular vitality, from boosting energy levels to enhancing muscle strength and promoting healthier skin.

As science continues to continue to explore the frontiers of health and longevity, supplements like Urolithin A play an increasingly vital role, and embracing these advancements in nutritional science is key to unlocking our full health potential today and in the years to come.

Authors
Jen Scheinman, MS, RDN, CDN

Written by

Jen Scheinman, MS, RDN, CDN

Senior Manager of Nutrition Affairs

Julie Faitg, PhD

Reviewed by

Julie Faitg, PhD

Lead Regulatory Affairs & Scientific Manager Alliances at Timeline

References
  1. Singh A, D’Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 (https://www.zotero.org/google-docs/?JdYdEk)

  2. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4 (https://www.zotero.org/google-docs/?JdYdEk)

  3. Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol Bethesda Md 1985. 2003;95(5):1851-1860. doi:10.1152/japplphysiol.00246.2003 (https://www.zotero.org/google-docs/?JdYdEk)

  4. Liu S, D’Amico D, Shankland E, et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(1):e2144279. doi:10.1001/jamanetworkopen.2021.44279 (https://www.zotero.org/google-docs/?JdYdEk)

  5. Singh A, D’Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5). doi:10.1016/j.xcrm.2022.100633 (https://www.zotero.org/google-docs/?JdYdEk)

  6. D’Amico D, Fouassier AM, Faitg J, et al. Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials. Published online June 20, 2023:2023.06.16.23291378. doi:10.1101/2023.06.16.23291378 (https://www.zotero.org/google-docs/?JdYdEk)

  7. Singh A, D’Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 (https://www.zotero.org/google-docs/?JdYdEk)

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Table of contents
Authors
Jen Scheinman, MS, RDN, CDN

Senior Manager of Nutrition Affairs

Julie Faitg, PhD

Reviewed by

Julie Faitg, PhD

Lead Regulatory Affairs & Scientific Manager Alliances at Timeline

Knowledge is power
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

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