Fermented Foods for Longevity and Healthy Aging
Fermented foods can support gut health and cellular function to promote longevity. Learn the best fermented foods and how to include in your diet.

What to know
Gut health shifts with age, impacting metabolism, brain, and immunity.
Fermented foods boost beneficial bacteria and support microbial diversity at the cellular level.
Postbiotics produced by the gut microbiome, such as Urolithin A, can support cellular health.
One to two servings of fermented foods daily can support healthy aging across the body.
Gut health may be one of the most overlooked yet powerful drivers of longevity. As we age, the gut microbiome, the community of bacteria and other microbes living in the digestive tract, becomes less diverse and resilient. These changes have been linked to everything from metabolic and immune health to cognition and mood.[1]
Research shows that diet can play a role in the health of our gut, and that fermented foods in particular can foster a healthier microbiome as you age.
Let’s review how the gut microbiome plays a role in aging and uncover what the latest research says about the benefits of fermented foods for longevity.

Why Does the Gut Microbiome Matter for Aging?
The gut does far more than help you digest food. It acts like a control center for many of the systems that determine how well you age. With aging, the microbiome typically loses diversity, leading to an imbalance between beneficial and potentially harmful microbes. The link between aging and the gut microbiome is so strong that scientists have classified it as one of the twelve hallmarks of aging.
One of the key ways the microbiome influences aging is through the compounds it produces, known as postbiotics. Postbiotics are bioactive substances created when gut microbes metabolize components of our diet that we don’t digest, like fiber or polyphenols. Probiotics are the bacteria themselves, while postbiotics are the functional outputs that can directly impact human health.
One example of a postbiotic is Urolithin A, which is produced when the gut microbiome metabolizes polyphenols called ellagitannins found in foods like pomegranates, berries, and walnuts. However, not everyone can efficiently produce Urolithin A, even if they regularly consume fermented foods. Research suggests that up to 60% of people lack the specific gut bacteria needed to generate meaningful amounts.[2]
This growing area of research has led scientists to study direct forms of Urolithin A, such as Mitopure®, for their potential effects on mitochondrial health and healthy aging. Learn more about the science behind Urolithin A and Mitopure® here.

Mitopure Softgels
4.5 (4270) · 95% recommend
The simplest form of Mitopure

What Are Fermented Foods and Why Are They Good for You?
Fermented foods are foods and beverages made through a natural process in which bacteria or yeast break down sugars and other compounds. This process not only helps preserve food but also creates beneficial compounds that may support gut and overall health.
Some fermented foods naturally contain probiotics, live microorganisms that can help support a healthier balance of bacteria in the digestive tract. Fermentation can also produce beneficial postbiotics and short-chain fatty acids (SCFAs), compounds linked to gut, metabolic, and immune health.
Common fermented foods include yogurt, kefir, kimchi, sauerkraut, miso, kombucha, tempeh, and certain aged cheeses.
How Much Fermented Food Should You Eat?
For healthy aging, one to two daily servings of fermented foods appear sufficient to support gut microbiome diversity, however there is no official recommendation for how much fermented food to eat daily. Increasing intake gradually may help reduce digestive discomfort, such as bloating or gas.
Consistency likely matters more than quantity. Regularly including fermented foods as part of an overall healthy diet may help support a healthier gut environment over time.
What Are The Benefits of Fermented Foods for Longevity?
Fermented foods may influence longevity in several ways, largely through their effects on the gut microbiome. As already discussed, aging is often accompanied by gut dysbiosis, the imbalance in the microbiome that can weaken the intestinal barrier, increase inflammation, and contribute to many of the biological changes associated with aging.[3]
Fermented foods may help counter some of these age-related shifts through a dual mechanism: introducing beneficial microbes into the gut while also supplying postbiotics like Urolithin A that support healthy aging.[4]
Can fermented foods support gut health?
Because fermented foods contain probiotics, they help maintain a healthier balance of microbes in the digestive tract.[5] By regularly eating these foods, you can help to increase microbial diversity.
The short-chain fatty acids (SCFAs) found in fermented food directly support gut health by nourishing the gut lining, supporting intestinal barrier integrity, and promoting a healthier inflammatory response.[6]
Together, these effects may help protect against some of the gut changes commonly associated with aging.
Can fermented foods support metabolic health?
As we get older, our metabolism naturally slows down. This can make it harder to regulate blood sugar, increasing the risk for weight gain and chronic diseases such as diabetes and heart disease. Interesting research suggests[7] that this risk is increased when muscle mass and function are also reduced.
While many may accept this as part of the aging process, eating more fermented foods may help by introducing bacteria that influence how we process fats and sugars. Studies have found that certain fermented foods containing Lactobacillus bacteria, such as yogurt, may help lower triglycerides, improve cholesterol levels, and promote healthier blood sugar control.[8]
When done consistently, consuming fermented foods may help promote steadier insulin levels and healthier triglyceride and cholesterol metabolism.
Can fermented foods support cognitive health and brain aging?
There is a close link between your gut and your brain, known as the gut-brain axis. Because the gut plays a role in regulating inflammation, its health may reduce the risk of age-related cognitive disorders[9] such as Alzheimer’s and Parkinson’s.
Eating fermented foods daily may protect the brain as we age. The beneficial bacteria in these foods support a stronger gut lining,[10] helping prevent harmful substances from entering the bloodstream and traveling to the brain. Postbiotics produced by a healthier microbiome may reduce oxidative stress,[11] further supporting brain health. Over time, this may support better memory, learning, and overall brain resilience.
Can fermented foods support mental health via the gut-brain axis?
About 1 in 5 older adults[12] experience mental health concerns. Due to the gut-brain connection, your gut not only supports brain health and cognition but can also influence mental health. When the gut microbiome is out of balance, studies show a link to higher rates of mental illness, such as anxiety and depression.[13]
Supporting a healthier, more diverse gut environment by eating fermented foods may, in turn, promote better mood and emotional resilience.
Can fermented foods lower inflammation?
Age-related inflammation, known as inflammaging, is common and it can increase the risk of chronic diseases. This inflammation starts at the cellular level but eventually can affect multiple organs.[14]
Eating fermented foods like yogurt, kefir (a drinkable yogurt), and cottage cheese may lower certain inflammatory markers.[15] Some research suggests they may support vital processes like autophagy,[16] the body’s natural cell “clean-up” system that removes damaged cells.
Can fermented foods support immune health as we age?
A healthy gut is equipped to fight off harmful substances and infections. In fact, about 70-80% of our immune system[17] is located in our gut, which shows just how important digestive health is for overall immunity.
Fermented foods may strengthen the body’s immune response by improving microbial diversity, which means a wider variety of beneficial bacteria thriving in the gut. A more diverse microbiome helps strengthen communication between the gut and immune cells, which can help your immune system respond more effectively when needed.[18]
In Summary: Fermented Foods and Longevity
Healthy aging starts in the gut. As the microbiome shifts with age, eating fermented foods like yogurt and kimchi can support its overall function. These benefits begin at the cellular level in the gut, where fermented foods can help reduce oxidative stress, support the body’s natural cell clean-up process, and promote healthier mitochondrial function.
By including fermented foods and preserving cellular health, you’re not just nourishing your gut, but reinforcing the foundation for longevity.
FAQs
What are fermented foods?
Fermented foods are foods or beverages made through a natural process where beneficial bacteria or yeast break down sugars. This process creates probiotics and other helpful compounds that can support gut and overall health.
How often should I eat fermented foods?
There is no official dietary guideline for how many fermented foods you should eat daily, but several organizations recommend that one to two servings per day,[19] such as 6 ounces of yogurt, kefir, or kombucha, or one tablespoon of miso, is often sufficient.
What are the best fermented foods to eat for longevity?
The best fermented foods include yogurt, kefir, fermented cottage cheese, kimchi, vegetable-based brine drinks, and kombucha tea. Some of these same compounds can be found in probiotic, prebiotic, and postbiotic supplements.
Can fermented foods replace probiotics?
In some cases, yes. If probiotics are taken for gut health, adding fermented foods to the diet may reduce the need for them. However, the live bacteria content of fermented foods[20] can vary based on the food and how long it is fermented, making it difficult to know how much you’re getting. Always consult your health care provider before making any changes to your supplement routine.
When should you eat fermented foods?
There is no perfect time of day to eat fermented foods, and consistency matters more than timing. Many people enjoy eating yogurt or cottage cheese for breakfast and incorporating foods like kimchi and sauerkraut with savory meals eaten later in the day. That said, there’s no reason you can’t enjoy any of these foods at any time.
Authors

Written by
Dietitian-Nutritionist, and Health Content Writer

Reviewed by
Director Science Communications
References
- ↑
Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T. (2020). The Gut Microbiome, Aging, and Longevity: A Systematic Review. Nutrients, 12(12), 3759. https://doi.org/10.3390/nu12123759
- ↑
Singh, A., D'Amico, D., Andreux, P. A., Dunngalvin, G., Kern, T., Blanco-Bose, W., Auwerx, J., Aebischer, P., & Rinsch, C. (2022). Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European journal of clinical nutrition, 76(2), 297–308. https://doi.org/10.1038/s41430-021-00950-1
- ↑
Mu H, Yao Y, Gong Y, Yang T. The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms. Curr Res Food Sci. 2025 Dec 31;12:101300. doi: 10.1016/j.crfs.2025.101300. PMID: 41551173; PMCID: PMC12809222
- ↑
Mu H, Yao Y, Gong Y, Yang T. The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms. Curr Res Food Sci. 2025 Dec 31;12:101300. doi: 10.1016/j.crfs.2025.101300. PMID: 41551173; PMCID: PMC12809222
- ↑
Dimidi, E., Cox, S. R., Rossi, M., & Whelan, K. (2019). Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease. Nutrients, 11(8), 1806. https://doi.org/10.3390/nu11081806
- ↑
Shin, Y., Han, S., Kwon, J., Ju, S., Choi, T. G., Kang, I., & Kim, S. S. (2023). Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease. Nutrients, 15(20), 4466. https://doi.org/10.3390/nu15204466
- ↑
Shou J, Chen PJ, Xiao WH. Mechanism of increased risk of insulin resistance in aging skeletal muscle. Diabetology & Metabolic Syndrome. 2020;12(14):14. doi:https://doi.org/10.1186/s13098-020-0523-x
- ↑
Ataie-Jafari, A., Larijani, B., Alavi Majd, H., & Tahbaz, F. (2009). Cholesterol-lowering effect of probiotic yogurt in comparison with ordinary yogurt in mildly to moderately hypercholesterolemic subjects. Annals of nutrition & metabolism, 54(1), 22–27. https://doi.org/10.1159/000203284
- ↑
Zhu S, Jiang Y, Xu K, Cui M, Ye W, Zhao G, Jin L, Chen X. The progress of gut microbiome research related to brain disorders. J Neuroinflammation. 2020 Jan 17;17(1):25. doi: 10.1186/s12974-020-1705-z. PMID: 31952509; PMCID: PMC6969442.
- ↑
Porras-García E, Fernández-Espada Calderón I, Gavala-González J, Fernández-García JC. Potential neuroprotective effects of fermented foods and beverages in old age: a systematic review. Front Nutr. 2023 Jun 15;10:1170841. doi: 10.3389/fnut.2023.1170841. PMID: 37396132; PMCID: PMC10313410.
- ↑
Bodur M, Kocaadam-Bozkurt B, Bozkurt O, Aslan S, Ağagündüz D. Fermented foods and brain health: Gut-brain axis mechanisms and clinical insights. J Nutr Biochem. 2026 Mar;149:110195. doi: 10.1016/j.jnutbio.2025.110195. Epub 2025 Nov 24. PMID: 41297620.
- ↑
Reynolds CF 3rd, Jeste DV, Sachdev PS, Blazer DG. Mental health care for older adults: recent advances and new directions in clinical practice and research. World Psychiatry. 2022 Oct;21(3):336-363. doi: 10.1002/wps.20996. PMID: 36073714; PMCID: PMC9453913.
- ↑
Xiong RG, Li J, Cheng J, Zhou DD, Wu SX, Huang SY, Saimaiti A, Yang ZJ, Gan RY, Li HB. The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components. Nutrients. 2023 Jul 23;15(14):3258. doi: 10.3390/nu15143258. PMID: 37513676; PMCID: PMC10384867.
- ↑
Li, X., Li, C., Zhang, W. et al. Inflammation and aging: signaling pathways and intervention therapies. Sig Transduct Target Ther 8, 239 (2023). https://doi.org/10.1038/s41392-023-01502-8
- ↑
Mu H, Yao Y, Gong Y, Yang T. The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms. Curr Res Food Sci. 2025 Dec 31;12:101300. doi: 10.1016/j.crfs.2025.101300. PMID: 41551173; PMCID: PMC12809222.
- ↑
Mu H, Yao Y, Gong Y, Yang T. The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms. Curr Res Food Sci. 2025 Dec 31;12:101300. doi: 10.1016/j.crfs.2025.101300. PMID: 41551173; PMCID: PMC12809222.
- ↑
Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021 Mar 9;13(3):886. doi: 10.3390/nu13030886. PMID: 33803407; PMCID: PMC8001875.
- ↑
Wastyk, H. C., Fragiadakis, G. K., Perelman, D., Dahan, D., Merrill, B. D., Yu, F. B., Topf, M., Gonzalez, C. G., Van Treuren, W., Han, S., Robinson, J. L., Elias, J. E., Sonnenburg, E. D., Gardner, C. D., & Sonnenburg, J. L. (2021). Gut-microbiota-targeted diets modulate human immune status. Cell, 184(16), 4137–4153.e14. https://doi.org/10.1016/j.cell.2021.06.019
- ↑
What Counts as a Serving of Fermented Foods? Nutrition. Published 2025. https://med.stanford.edu/nutrition/education/Resources/Fermenting-the-Facts/What-Counts-as-a-Serving-of-Fermented-Foods.html
- ↑
What Counts as a Serving of Fermented Foods? Nutrition. Published 2025. https://med.stanford.edu/nutrition/education/Resources/Fermenting-the-Facts/What-Counts-as-a-Serving-of-Fermented-Foods.html

·
Nutrition·
Studies·
What Centenarians Reveal About Longevity and Immune Health

·
Skincare·






