Mitopure®: A New Way to Fight Visible Aging

Skin Aging Is More Than Skin Deep

When it comes to skin aging, it’s easy to focus on what we see in the mirror: fine lines, wrinkles, changes in texture, and loss of firmness. But those visible changes are only the surface expression of deeper biological processes unfolding inside the skin.

In many ways, skin acts as a biomarker of how we are aging internally. As the body’s largest organ and first line of defense, it reflects changes in cellular energy, repair capacity, and resilience that occur as we get older.

Now, there is a clinically studied way to support skin’s visible aging at its source. Mitopure® is a highly pure, clinically validated form of Urolithin A and the foundational ingredient in Timeline’s skincare line.

Read on to learn what makes Mitopure the science-backed approach to better skin health.

What Causes Skin Aging?

Skin aging is shaped by both internal biological changes and external environmental exposures. While aging is inevitable, how quickly and how visibly it shows up is largely influenced by the cumulative stress placed on skin cells over time.

Skin is a high-turnover organ. Its outer layers are constantly renewed in order to maintain barrier function, structure, and resilience. This continuous renewal requires a significant amount of energy, coming from the mitochondria.^[1]

As we age, mitochondrial function declines, limiting the energy available for essential processes such as collagen production, barrier maintenance, and cellular renewal.

External factors accelerate aging. Ultraviolet radiation, pollution, smoking, and other environmental stressors place additional strain on skin cells, overwhelming their ability to repair and protect themselves. The result is not only more wrinkles, but weaker skin that is more vulnerable to damage and slower to heal.

This is why supporting the biological systems that power skin health, particularly cellular energy production and renewal, is essential for maintaining both how skin looks and how it functions as we age.

Introducing Mitopure for Your Skin

Mitopure is a highly pure form of the postbiotic Urolithin A. It has been clinically studied for its ability to activate mitophagy, a critical cellular recycling process that helps maintain healthy cellular function and supports resilience with age.^[2]

Urolithin A is naturally produced by the gut microbiome after we eat foods rich in ellagitannins, bioactive compounds found in pomegranates, walnuts, and certain berries. When these foods are eaten, specific gut bacteria convert ellagitannins into Urolithin A.^[4]

However, not everyone can produce meaningful amounts of Urolithin A. Research shows that fewer than 30% of people have the gut microbiome needed to produce Urolithin A, and most people are not eating enough of the dietary precursors to support meaningful production. As a result, most of us are missing out on its potential benefits.^[3]

Mitopure was developed to provide a consistent, highly pure source of Urolithin A, without relying on gut microbiome variability or dietary intake.

After over a decade of studying this longevity molecule, our research team began investigating what would happen if Mitopure were applied topically. Could it confer benefits to our skin?

The results amazed even us, so let’s unpack them.

Mitopure Energizes Skin Cells

Preclinical studies in human skin cells found evidence of increased activation of cellular renewal processes after 72 hrs. This increase helps maintain cellular powerhouses^[5] and supports their recycling and replacement, which helps explain how Mitopure contributes to improvements in skin appearance and function observed in human studies.

Mitopure Reduces Wrinkles

As skin ages, fine lines and wrinkles become more visible. In human clinical studies, Mitopure was shown to visibly reduce wrinkle depth and volume, with improvements observed as early as two weeks.^[6]

In a split-face study design, topical application of Mitopure resulted in measurable reductions in wrinkle depth, volume, and overall appearance compared to placebo. After eight weeks of use, these improvements were statistically significant compared to the untreated side.

Mitopure Supports Collagen

Mitopure has been clinically studied for its ability to address key biological drivers of skin aging. Evidence from human skin biopsies of women ages 50–70 shows that topical application of Mitopure activates genes involved in collagen organization and assembly.^[7]

These genes are typically downregulated with age, but after eight weeks of use with Mitopure, they were significantly upregulated. In effect, Mitopure shifted collagen-related gene activity toward a profile more typical of younger skin cells.

Mitopure Protects the Skin From Photodamage

Our studies also show that Mitopure helps protect skin from photoaging, the damage caused by repeated sun exposure. This is especially meaningful given that sun damage is responsible for up to 80% of visible skin aging.

To study this, we conducted a UVB erythema trial in 22 adults using a cream containing 1% Mitopure. The purpose of this study was to assess redness and inflammation, which are among the earliest visible signs of sun damage.

When applied after UV exposure, skin treated with Mitopure showed a significant reduction in erythema compared with untreated skin. These results suggest that Mitopure helps the skin recover more effectively from UV-induced damage, supporting its role in protecting against photoaging.

Mitopure Skin Longevity Essentials

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Mitopure is Gentle on the Skin

Strong science only matters if an ingredient is well tolerated. In addition to studying Mitopure for its effects on cellular vitality, researchers also carefully evaluated its safety for topical use.

In a study involving 109 men and women, Mitopure showed excellent tolerability. Using a standard human repeat insult patch test (the gold standard for irritation and sensitization) with Mitopure at a 1% concentration in a base cream, researchers observed no signs of irritation or skin sensitivity.^[8]

These findings confirm that Mitopure is gentle, well tolerated, and suitable for regular use, allowing it to be incorporated into skincare routines with confidence.

Want to see the benefits of Mitopure for your skin? Explore the new skin health range from Timeline.