5 reasons biohackers love this mitochondrial supplement

Explore the top five reasons why Mitopure is the biohacker's go-to for boosting energy and maintaining peak performance.

5 reasons why Mitopure is a biohacker's go-to
What to know
  • Biohackers aim to optimize health, longevity, and performance by leveraging the latest science and technological advances

  • Mitochondrial health is key to biohackers' strategy for increasing both mental and physical performance

  • Mitopure® (Urolithin A) is a favorite biohacking mitochondrial support supplement due to its unique ability to optimize mitophagy - cellular recycling of mitochondria

  • Clinical trials with Mitopure demonstrate its ability to improve cellular energy and muscle strength and endurance

  • Topical application of Mitopure has been clinically proven to re-energize cells to target factors that contribute to aging skin

In the quest for peak performance and longevity, an innovative community known as biohackers is leading the charge, employing a series of strategies to enhance the body and mind's potential. Biohacking, at its core, is about taking control of your own biology using the latest scientific findings and technological advancements. From nutritional supplementation and sleep optimization to cutting-edge science, biohackers are redefining what it means to live a high-performance lifestyle.

As biohackers focus on optimizing every aspect of human biology, it is no surprise that mitochondrial health has emerged as a top area of focus. They understand that mitochondrial function is key to achieving the pinnacle of health.

Read on as we explore the top 5 reasons why biohackers love Mitoupure and how it stands out from other mitochondrial support supplements.

Biohackers understand the significance of mitochondrial health

Biohackers understand that mitochondrial health is the foundation of good health. Mitochondria are the powerhouses within our cells that play a crucial role in generating the energy our cells need to function. These cellular organelles take the food that we eat and the air that we breathe, converting it into our energy currency, adenosine triphosphate (ATP).

As we age, maintaining optimal mitochondrial health becomes essential as it has been well established that mitochondrial decline is one of the biological hallmarks that drive the aging process.

Mitochondrial decline contributes to many aspects of aging, from loss of muscle strength to declining immune function and even skin aging.

3D representation of an active mitochondria

Mitopure and mitochondrial support

Urolithin A, the active compound in Mitopure, has garnered attention for its potential to support mitochondrial health. It works in a unique way by targeting a mitochondrial quality control mechanism called[1] mitophagy.

Clinical studies using Mitopure have demonstrated its ability to improve cellular energy, and muscle strength and endurance.[2]Topical use of Mitopure has been shown to target both the intrinsic (internal) and extrinsic (external) factors associated with aging.[3]

The biohacking community is at the forefront of health innovation, eagerly embracing new scientific discoveries that push the boundaries of health and performance. With that in mind, here are the top 5 reasons that biohackers are raving about Mitopure and making it a foundational part of their supplement stack.

1. Targets key hallmarks of aging

As we age, our mitochondria function declines. And with age, mitophagy rates also, unfortunately, decline. This means that more dysfunctional mitochondria collect in the cell, contributing to less efficient energy production and cell function.

Biohackers know that Mitopure directly targets these two hallmarks of aging by promoting mitophagy. Mitopure helps remove dysfunctional mitochondria and replace them with more efficient ones, thereby improving the overall energy production of cells.

This boost in cellular energy is fundamental for everything from heightened physical endurance and faster recovery times to improved mental clarity and alertness. For biohackers, who often seek to optimize every aspect of their physiological functioning, the increased cellular energy provided by Mitopure is a game-changer, enabling them to perform at their peak levels more consistently.

2. Potential for enhanced performance

Beyond its role in combating aging, Mitopure's potential for enhancing performance has captivated the biohacking community. By optimizing mitophagy, Mitopure ensures a supply of efficient and healthy mitochondria, which are crucial for energy production. This enhanced cellular energy is not just about longevity; it translates into improved physical endurance and overall enhanced performance in daily activities. Whether it's athletes seeking an edge in their physical endeavors or professionals looking for increased stamina, Mitopure offers a promising avenue for anyone aiming to elevate their performance to the next level.

Man's muscle close up during excercise

3. Improved muscle strength and endurance

The appeal of Mitopure extends to the realm of athletic performance and physical fitness due to its ability to target muscle health. Healthy and efficient mitochondria are essential for fueling muscles, supporting longer and more intense exercise sessions, and facilitating faster recovery.

What’s more, muscle decline starts as early as our 30s,[4] and finding interventions to slow this down can make all the difference in how well we can maintain our muscle and mobility as we age.

Clinical trials have shown that Mitopure improves both muscle strength and muscle endurance,[5]making it a meaningful supplement for those seeking to preserve and enhance muscle health over time. By boosting mitochondrial function, Mitopure helps maintain the energy supply muscles need to perform optimally, even under the stress of aging or intense physical activity. This not only aids in sustaining athletic performance but also contributes to overall vitality and the ability to lead an active lifestyle at any age.

4. Energizes cells for healthier skin

Skin is the largest organ in the body, and often, it is one of the first to show signs of aging. Just like other cells in our body, skin cells rely on lots of energy from our mitochondria; however, as we age, these powerhouses become dysfunctional, leading to signs of aging such as dullness and wrinkles.

Topical application of Mitopure is clinically proven to re-energize skin cells, helping them to combat both intrinsic and extrinsic factors leading to skin aging.

The result: healthy, resilient, and more youthful-looking skin

5. Unparalleled science

The science behind Mitopure is what sets it apart in the world of supplements, especially among the discerning eyes of the biohacking community. Rooted in years of rigorous research and clinical trials, Mitopure has established itself as one of the few supplements with a strong scientific standing. Its efficacy is backed by studies published in reputable scientific journals, detailing its profound impact on cellular health through mitophagy.

For people who thrive on solid evidence with measurable results, the robust scientific foundation of Mitopure makes it a trusted component in the quest for optimized health.

Urolithin A vs Other Molecules

Comparing Urolithin A to other mitochondrial supplements

Mitopure isn’t the only player in the mitochondrial game, yet it remains the clear foundational choice for biohackers' mitochondrial stack. Let’s see how other mitochondrial support supplements compare.

Coenzyme Q10 (CoQ10)

CoQ10 is a well-known antioxidant that plays a role in the electron transport chain of mitochondrial respiration. While both Urolithin A and CoQ10 aim to support mitochondrial function, Urolithin A's unique mechanism of action in promoting mitophagy and biogenesis sets it apart. While CoQ10 helps in the efficiency of existing mitochondria, Mitopure goes a step further by clearing out dysfunctional mitochondria to make room for new, healthier ones.

NAD Precursors

NAD precursors, such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), are used to boost NAD+ levels, a crucial coenzyme for metabolic processes and mitochondrial function. By replenishing cellular NAD+ levels, they support energy metabolism and overall cellular health.

Mitopure offers a different approach to cellular health by specifically targeting and enhancing mitophagy, the process of renewing and recycling mitochondria. While NR and NMN support the function of mitochondria indirectly by maintaining NAD+ levels, Mitopure directly influences the health and quality of mitochondria.

PQQ (Pyrroloquinoline Quinone)

PQQ is an antioxidant that supports mitochondrial function and biogenesis (the creation of new mitochondria. It is believed to work by activating cellular pathways involved in energy metabolism and mitochondrial health, as well as providing antioxidant protection.

While PQQ will support new mitochondria development, there is no clinical evidence demonstrating that it helps to improve mitophagy. Mitopure is the only supplement that has been proven to trigger mitophagy in humans.

Wrapping up

Mitochondrial health is a cornerstone of overall well-being for biohackers and the general population at large. Mitopure (Urolithin A) has emerged as a unique and targeted supplement in the biohacking toolkit. It focuses on supporting mitochondrial function through mitophagy, distinguishing it from other supplements in the space. As biohackers continue to seek innovative ways to optimize their health and performance, Mitopure stands out as a promising ally in the quest for enhanced vitality.


Jen Scheinman, MS, RDN, CDN

Written by

Senior Manager of Nutrition Affairs

Julie Faitg, PhD

Reviewed by

Lead Regulatory Affairs & Scientific Manager Alliances at Timeline


  1. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4 (https://www.zotero.org/google-docs/?hHSWii)

  2. Liu S, D’Amico D, Shankland E, et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(1):e2144279. doi:10.1001/jamanetworkopen.2021.44279 (https://www.zotero.org/google-docs/?hHSWii)

  3. D’Amico D, Fouassier AM, Faitg J, et al. Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials. Published online June 20, 2023:2023.06.16.23291378. doi:10.1101/2023.06.16.23291378 (https://www.zotero.org/google-docs/?hHSWii)

  4. Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol Bethesda Md 1985. 2003;95(5):1851-1860. doi:10.1152/japplphysiol.00246.2003 (https://www.zotero.org/google-docs/?hHSWii)

  5. Singh A, D’Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5). doi:10.1016/j.xcrm.2022.100633 (https://www.zotero.org/google-docs/?hHSWii)

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

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