The Night CreamRefill

Helps skin regenerate overnight to wake up re-energized with a more youthful appearance. Clinically proven to reduce the appearance of fine lines and wrinkles. Intensely hydrating, leaving the skin barrier feeling strengthened and more resilient. Skin texture and grain feel smoother and more even. Melts onto the skin and leaves it soft and with a velvety, silky feeling. Powered by Mitopure®. For all skin types and genders. Includes one 50mL pre-filled insert. Permanent glass outer packaging not included.

HSA/FSA eligible with TrueMed · Get pre-qualified

Free US shipping · International shipping

Prices excl. VAT

  • Revitalizes

  • Regenerates

  • Reinforces

  • Hydrates

The Night Cream Refill
The Night Cream Refill
The Night Cream Refill
The Night Cream Refill
The Night Cream Refill
The Night Cream Refill

Looking for the whole product?

If this is your first time purchasing The Night Cream, shop the full set including permanent refillable packaging.

Shop now
Woman using the Night Cream
Mitopure (Urolithin A) Molecule

The first and only bioactive clinically proven to re‑energize cells

Building on prior research, we have now demonstrated that when applied topically our breakthrough ingredient supports cellular renewal from within the skin cells, for youthful looking skin, full of life and energy.

Learn more

The proven benefits of the Night Cream

The Night Cream has been proven to revitalize, regenerate, reinforce and hydrate skin’s appearance overnight so that your skin benefits from the important period of rest and rejuvenation.



Re-energizes skin cells for a revitalized youthful-looking skin



Supports the natural regeneration process of the skin



Nourishes and protects for more resilient, youthful-looking skin



Locks-in moisture for a well-hydrated skin

Tight framed portrait of a person's face with great skin

Clinical results validated by users

We rigorously study the impact of our products to make sure they are both effective and loved by the people using them. Based on a 3-week user trial of 30 healthy women aged 40 to 65 years.

  • 80%

    agree skin appears to regenerate overnight and wakes up re-energized with a more youthful appearance

  • 83%

    agree skin awakens with a healthy glow, morning after morning

  • 93%

    agree skin feels protected, stronger and revitalized

  • 93%

    agree skin feels immediately hydrated, nourished and supple

  • 87%

    agree skin looks visibly firmer, more lifted and elastic

People smiling while holding The Night Cream

High-performing, science-selected, sustainably sourced ingredients

Our exclusive, patented ingredient Mitopure® has been placed alongside carefully selected skin bioactives, designed to help the skin protect itself from external aging triggers, while enhancing intrinsic cell renewal.

How to apply

  • Step 1

    Apply in the evening, by itself or after the Serum. Take desired amount of product onto clean fingertips and smooth over the face, neck and décolleté. Start from the center of your face outward.

  • Step 2

    In upward sweeping motions, massage the cream along your jawline. Sweep from your nose to your ears and across your forehead and massage cream over the cheeks to your temples.

  • Step 3

    Apply from the base of the neck to the tip of the chin. Take any excess cream and massage over the décolleté.

How we package our products matter

We are very mindful of our environmental impact and committed to providing packaging that’s as durable and sustainable as possible.

  • Refillable packaging

    We reduce waste with a refillable system. After your first purchase, you will have the ability to keep most of the packaging components and just buy the refills.

  • Sustainable materials

    The glass and plastic we use in our packaging are 100% recyclable. Our cartons are made of FSC-certified, biodegradable paper.

  • Glass bottle

    Glass is the ideal material as it’s made from natural raw materials and is 100% endlessly recyclable.

The Night Cream refillable packaging

We love questions

Have more questions? Visit our Help Center or inquire at

Discover our full range of products

Shop skin health
Shop skin health

Knowledge is power
Sign up to our newsletter

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

© 2024
© 2024