New Study: Urolithin A Revitalizes an Aging Immune System

When most of us think about immune health, we picture “boosting” our defenses during cold and flu season. But immune health is about so much more than avoiding the sniffles. A strong and balanced immune system plays a central role in how we age. It helps regulate a healthy inflammatory response and supports vitality throughout life. Unfortunately, the immune system naturally ages, along with the rest of our body.

This is why Timeline is proud to announce another major milestone: the publication of our latest clinical trial in the top medical journal Nature Aging. Conducted in collaboration with world-renowned scientists, the study demonstrates how Urolithin A, the postbiotic in Mitopure®, can help maintain the immune system by targeting its powerhouse, the mitochondria.

Understanding Immune Aging

Immune aging is increasingly recognized as a key driver of biological aging and a strong predictor of vitality. Recent research goes so far as to suggest that the health of our brain and immune system are the two organ systems most closely linked to how healthy we live.^[1]

As we age, our immune system becomes less efficient. At the same time, it can become overactive.

These changes are deeply tied to how we age. That’s why targeting immune aging is emerging as a promising strategy to promote healthy longevity.

Our New Study: Mitopure Improves Key Markers of Immune Health

Can Mitopure support an aging immune system?

To answer this question, Timeline partnered with Dr. Dominic Denk and Professor Florian Greten at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, as well as the team at Dr. Eric Verdin’s lab at the Buck Institute for Research on Aging.

In this double-blind, placebo-controlled trial, 50 healthy adults between the ages of 45 and 70 were randomized to receive 1000 mg daily of Mitopure, Timeline’s patented Urolithin A supplement, or a placebo over a 28-day period.

Researchers then measured the impact of this intervention on key hallmarks of immune aging.

The results were striking.

What Did the Study Find?

The results revealed that taking 1000 mg of Urolithin A can support a youthful, resilient immune system. Here’s what the study found:

• Supports immune fitness: Urolithin A increased the number of naïve CD8+ T cells. These are the fresh, responsive cells that decline steadily with age. These cells also showed less “exhaustion,” suggesting they were better equipped to support immune health.
• Healthier energy metabolism: Immune cells from the Urolithin A group shifted toward cleaner fuel sources like fatty acids and amino acids, instead of relying on glucose. This metabolic switch supports a more efficient and healthy inflammatory response.
• Stronger mitochondria: The intervention triggered mitochondrial biogenesis, the creation of new and healthy mitochondria.
• Supports healthy immune cell activity: When challenged ex vivo (using human cells in a lab setting), immune cells from participants taking Urolithin A cleared E.coli particles more effectively, supporting a more youthful immune cell profile associated with healthy aging.
• Safe and well-tolerated: The supplement was well-tolerated and produced no serious side effects.

Why This Matters

Immune aging is not just a background process. It is a key factor that influences how we age.

For Timeline, this study represents more than just exciting results. Published in Nature Aging, it marks another major milestone in our mission to deliver clinically validated, science-backed solutions for healthy aging.

Daily supplementation with Urolithin A may help support immune fitness by promoting mitochondrial health. While further research is needed to fully understand the long-term benefits, this study provides compelling evidence that supporting mitochondrial health is a key aspect of maintaining immune health with age.

Mitopure Gummies

4.7 · 594 reviews

A strawberry-flavored dose of cellular energy

Buy now