Mitopure®: A new way to fight aging

Mitopure® is clinically proven to protect skin cells from aging. Fighting age-related decline by enhancing skin energy, youthfulness and resilience.

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What to know
  • Mitopure® is a highly purified form of Urolithin A, a naturally-occurring anti-aging compound. It is backed by over a decade of scientific research in cellular health.

  • Mitopure® has been clinically proven to help fight against intrinsic and extrinsic aging by supporting the pathway of energy production in cells that are at the heart of youthful-looking skin.

  • It starts to visibly reduce the appearance of wrinkles after only 2 weeks of use.

  • It is clinically proven to support collagen production and assembly, and protect skin from environmental damage (photo-aging)

  • On top of all these benefits Mitopure is kind to skin - hypoallergenic and non-irritating

What is Mitopure®?

Mitopure® is a highly concentrated source of Urolithin A. The first nutrient clinically proven to trigger a crucial recycling process within our cells preventing age-related cellular decline.

300+ Pre-clinical and clinical studies have explored the potential benefits of Urolithin A.

What is Urolithin A, and where does it come from?

Ellagitannins are potent bio-actives found in certain foods including pomegranates. When we eat foods containing ellagitannins, our gut bacteria break them down and transform them into something called Urolithin A. However, not everyone can make enough Urolithin A from the ellagitannins they consume. In a study conducted in 2017 by the Spanish Laboratory of Food & Health, researchers found that the amount of Urolithin A participants produced after consuming pomegranate juice varied widely, with only 40% of participants producing sufficient amounts of Urolithin A to confer health benefits.[1] Real evidence that we’re not always exactly what we eat! And also a real shame, because Urolithin A is known to energize mitochondria and as a result improve cellular health – and this is something we can all use.

Knowing this, researchers wondered if they could bypass the step of having to eat ellagitannin-rich foods and relying on gut bacteria to convert them, and instead produce a concentrated form of Urolithin A that everyone could benefit from. With this, Mitopure® was born!

Mitopure® is a proprietary, patented, and highly pure form of Urolithin A that provides 6x the amount of this beneficial substance as a glass of pomegranate juice. It is backed by more than a decade of scientific research into cellular health and proven to confer multiple health benefits including improved muscle strength and endurance. But what if this amazing substance were applied topically? Could it confer benefits to our skin?

Skin Energy and Why it Matters for Aging

Swiss scientists have conducted multiple laboratory tests and clinical studies to explore the effects of Mitopure®(Urolithin A) on skin health. They discovered that Mitopure® actually energizes skin cells from within. This is incredibly important because the skin requires a lot of energy in order to combat intrinsic (biological) and extrinsic (environmental) factors at the heart of skin aging.

You can read more in our previous blog What happens when skin ages?, however let’s recap quickly on a couple of important points:

Intrinsic aging: Processes inside the skin, including collagen production and deposition, decline with age. Collagen is the scaffolding of the skin, providing strength and resilience. Its production starts slowing down in our early adulthood and declines by about 1-1.5% each year.[2]

Extrinsic aging: Skin aging can be aggravated by certain lifestyle choices like smoking and external factors such as sun exposure and pollution. Ongoing sunlight exposure and smoking lead to a reduced efficiency in eliminating free radicals which can further slow down collagen synthesis.[3]

Luckily, Mitopure® powers up the cellular powerhouses of skin cells to help protect against these aging factors. But how does it work exactly?

Mitopure® energizes skin cells

In our blog Skin health, aging and the cellular powerhouse we learned that skin needs a lot of energy to stay health and combat aging. Mitopure® has been clinically proven to support the pathway of energy production in cells that are at the heart of youthful looking skin.

What’s the evidence? Pre-clinical studies in human skin cells found evidence of increased activation of cellular renewal processes after 72 hrs. This increase helps maintain the recycling and replacing of old cellular powerhouses – which is good news for our skin!


Mitopure® leaves skin with a more youthful appearance

As skin ages, fine lines and wrinkles start to appear. Mitopure® has been proven to start visibly reducing wrinkle depth and volume after only 2 weeks of use.

Before & After

What’s the evidence? A human clinical study demonstrated that the application of Mitopure® to skin in the area of the crow’s feet (fine lines and wrinkles next to the eye) led to a reduction in wrinkle depth, volume and appearance.

Change in wrinkle depth

Mitopure® helps enhance skin’s resilience:

Mitopure® is clinically proven to help fight off both intrinsic and extrinsic aging factors by supporting collagen assembly and protecting skin from environmental damage (photo-aging).

What’s the evidence? Mitopure® is clinically proven to support the processes inside the skin cells that power up collagen assembly and formation.

Collagen Assembly

Mitopure® is also clinically proven to protect skin against the damage from photoaging.

Protects against photoaging

Mitopure® is gentle on the skin

The evidence for Mitopure® and its role in cellular vitality is impressive, but none of that matters if it irritates the skin. The good news is that the Swiss scientists who pioneered Mitopure® also tested it for safety – and across 112 subjects saw no irritation or sensitivity at all!

Gentle to the skin

Mitopure® is dermatologist tested and approved as safe, kind to skin, and hypoallergenic. So, you can use products containing Mitopure® with confidence.

Want to see the benefits of Mitopure® for your skin? Explore the new skin health range from Timeline.

The Day Cream
The Day Cream

4.6 · 78 reviews

Redensifies the skin's appearance. Powered by Mitopure®

Buy now
The Night Cream
The Night Cream

4.7 · 110 reviews

Regenerates the skin's appearance. Powered by Mitopure®

The Serum
The Serum

4.6 · 109 reviews

Lifts the skin. Powered by Mitopure®

Amazentis studies

Internal Amazentis study 1: Pre-clinical trial; Increased expression of mitophagy marker Park2 after 72 hrs. treatment; Blocked UV-mediated increase in inflammatory marker PGE2; UA at high dose of 1% induced mitochondrial abundance in reconstituted human epidermis (RHE)

Internal Amazentis study 2: Pre-clinical trial; Reduced collagen degradation and increased mitochondrial health biomarkers in human keratinocytes with Urolithin A; Increased markers of mitochondrial respiration

Internal Amazentis study 3: Dermatologically tested on 112 men and women. Safety and tolerability demonstrated using a human repeat insult patch test with Mitopure 1% in a base cream

Internal Amazentis study 4: Human clinical trial assessing erythema severity (anti-inflammatory effect of UA) Based on a 24-hour randomized clinical trial of 22 healthy men and women aged 18 years and older. Single application before irradiation.

Internal Amazentis study 5: Human clinical trial: Visibly reduces the appearance of fine lines and wrinkles based on a 8-week randomized clinical trial of 48 healthy women aged 50 to 75 years. Twice-daily, morning and evening, application.


Science Editorial Staff


Editorial Staff


  1. García-Villalba, R., et al., Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract. Journal of Agricultural and Food Chemistry, 2017. 65(27): p. 5480-5493.

  2. Reilly, D.M. and J. Lozano, Skin collagen through the lifestages: importance for skin health and beauty. Plastic and Aesthetic Research, 2021. 8: p. 2.

  3. Knuutinen, A., et al., Smoking affects collagen synthesis and extracellular matrix turnover in human skin. British Journal of Dermatology, 2002. 146(4): p. 588-594.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

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© 2024