How to stimulate cellular renewal for optimal health

Revitalize your health with cellular renewal strategies for longevity, including diet, exercise, and supplements like Mitopure®.

Illustration depicting cellular renewal
What to know
  • Cellular renewal is a crucial process for maintaining the optimal health and function of the body

  • Several lifestyle factors can negatively impact cellular renewal, including aging, poor sleep, a pro-inflammatory diet, lack of exercise, stress, and UV damage

  • Effective strategies to enhance cellular renewal include calorie restriction or fasting, polyphenol-rich foods, regular exercise, and supplements like Mitopure®

It’s a new year again, and like many of us, you’re probably looking for a fresh way to jumpstart your health habits. While this is an exciting time to focus on new beginnings, figuring out the best direction to renew your health can also feel overwhelming.

This year, we’re using this opportunity to commit to revitalizing our health at its core: our cells. This isn't about fleeting resolutions; it's about embarking on a personal journey towards a healthier you, now and in the future, through cellular renewal.

Renewing your cells to support whole-body health starts in the mitochondria, those small but mighty energy centers of our cells. Unfortunately, this cell renewal process becomes less efficient as we age.

But, there is good news backed by scientific evidence - the proper diet, exercise, supplements, and a focus on skin health can facilitate cellular renewal at any age. So sit back and soak in the small steps you can take to stimulate cellular renewal and (Re) New your health for the New Year.

Degrading cell

What is cellular renewal?

Cellular renewal is a natural, biological process in which old cells and their components, are rejuvenated and replaced by new, healthy cellular parts. This process is critical for maintaining the health and optimal function of various organs and tissues in the body.[1]

Regularly optimizing cellular renewal can lead to an improved healthspan and the quality of our lived years.

Over time, the cells in our body become senescent or what are now commonly known as “zombie cells.” This means they grow old and no longer serve a beneficial purpose in the body. When this happens, these cells continue producing compounds that can trigger chronic inflammation, also called “inflammaging.”

Luckily, accelerating aging does not have to be part of your blueprint. Making intentional lifestyle choices can support this natural process.

Why is it necessary for health?

Cellular renewal is necessary for many aspects of health, and our health habits should always have cell renewal at the forefront. Here are some key benefits of cellular renewal.

Healthy aging

Cellular renewal is important for overall health and longevity. This process removes dead, damaged cells and regenerates them into more functional, healthy cells that can slow aging.

Skin health

As we age, our skin cells become less efficient at renewing themselves from the inside, increasing the risk of skin aging and thinning skin on the outside.[2]

Muscle strength and function

Cellular renewal also supports muscle strength and function. This is exciting news because lean muscle mass is associated with improved longevity and overall health.[3]

Energy

Renewing your mitochondria improves their functionality, infusing you with more steady, reliable energy to do the things you need (and want) to do.

Immunity

Impaired cellular health can negatively impact immunity. Supporting more efficient cellular renewal through the lifestyle promotes a healthy immune system.[4]

Neurological health and focus

As our cells age, the cells involved in brain health and cognitive function also start to decline. Stimulating cellular renewal, however, can help delay this process and improve brain health and focus.[5]

Factors affecting cellular renewal

Several factors can negatively affect cellular renewal, slowing down or halting the process that supports longevity.

Here are a few of the biggest factors to target if your goal is to lead a longer, healthier life.

  • Inflammatory diet - A diet high in pro-inflammatory foods such as processed foods, alcohol, added sugar, and red meat can negatively impact the health of our cells.
  • Poor sleep - Research shows poor sleep can increase cellular injury and delay repair.[6]
  • Lack of exercise - A sedentary lifestyle and lack of exercise can depress the cellular renewal process, as your body will not work as efficiently overall.[7]
  • Stress -Chronic stress can delay cellular renewal in the body.[8]
  • UV damage/photodamage - Excess UV damage from the sun and subsequent photodamage can delay cellular renewal and accelerate aging. This can occur both inside and outside the body. Even if you have UV damage, there are still things you can do to reverse skin damage and promote more youthful skin.[9]

Strategies to stimulate cellular renewal

The good news is you can stimulate cellular renewal in your body, regardless of your current habits. Here are the different areas to address to enhance this process.

Calorie restriction and fasting

Both continuous daily calorie restriction and several fasting methods have been shown to successfully stimulate cellular renewal for longevity.

Calorie restriction

Continuous calorie restriction is a more traditional approach to reducing calorie intake to create a calorie deficit throughout an entire day of eating. The goal is to consume fewer calories while ensuring you get all the necessary nutrients for health.[10]

Studies show calorie restriction can slow the aging process by enhancing aspects of cellular repair. It is thought to do this by reducing oxidative stress and inflammation and stimulating autophagy, an essential cellular cleanup process.

Calorie restriction, if practiced correctly, can also improve metabolic health and reduce the incidence of inflammation. [11]

It is critical that you still meet your nutritional needs, even if your calorie intake is lower. It’s highly recommended that you work with a trained nutrition professional, such as a Registered Dietitian figure out what your calorie intake should be and to determine if you are meeting all your nutrition needs.

Fasting

Fasting can be approached in various ways, including intermittent fasting, time-restricted eating, and periodic fasting on certain days of the week. Regardless of the approach, all fasting methods effectively trigger autophagy, the cellular recycling process.

During fasting times, cells have more opportunity and time to remove dysfunctional components and repair themselves. This can lead to cellular rejuvenation, enhanced repair processes, and optimized cell performance throughout the body.[12]

It’s important to remember that fasting and calorie restriction is not for everyone. While some people thrive on these protocols, others find them difficult to follow or struggle to reach their nutrient goals.

While both of these eating methods have been shown to be equally beneficial for longevity and long-term health you need to find the best style of eating for you.[13]

Polyphenol-rich diet

It’s easy to get caught up with calorie intake, but what you eat also plays just as much of an important role in cellular renewal. One of the best places to start is by prioritizing polyphenol-rich foods. Polyphenols are beneficial plant compounds with anti-aging, antioxidant, and anti-inflammatory properties.[14]

The best polyphenol food sources include:

  • Pomegranates
  • Berries - blueberries, blackberries, strawberries
  • Artichokes
  • Onion
  • Spinach
  • Olive oil
  • Dark chocolate - consume in moderation to minimize added sugar intake
  • Spices - cloves, peppermint, star anise
  • Green and black tea
  • Red wine - While consuming wine in moderation is one way to consume polyphenols, it's not recommended to start if you don’t already drink it.

Incorporating these foods and beverages can help stimulate cellular repair.

Woman exercising

Exercise

There are so many reasons why exercise is good for you - but its benefits truly start at the cellular level. Regularly engaging in endurance and strength training exercises helps fuel mitochondrial health and, thus, overall cellular health.

Endurance

Incorporating resistance training into your weekly routine helps increase muscular strength, stamina, and overall cellular health. Examples of endurance exercises you can try include walking, running, biking, intervals, and weight training. You can build your endurance with practice and exercising in various [14]heart rate zones to challenge the body and build overall fitness.

Strength training

Resistance exercises include body weight, free weights, weight machines, or resistance bands. Combining resistance exercises with adequate dietary protein can maximize muscle health and cellular repair processes.

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Supplements

If you need an extra boost to your cellular health, adding a supplement like Mitopure® can help you make the most out of your lifestyle efforts.

Mitopure is a clinically validated dose of Urolithin A, that has been shown to support cellular renewal.[15]

Nutrition supplments

Mitopure’s nutrition line has a 500 mg dose of Urolithin A, which has been clinically shown to improve cellular energy and increase muscle strength and endurance[16]. Research shows that most people lack the gut bacteria necessary to produce Urolithin A from food; thus, direct supplementation may be required.[17]

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Skin health

As we age, our skin cells have less energy and are less efficient at renewing themselves from the inside, leading our skin to visibly age on the outside.

Recent findings from randomized clinical trials show Urolithin A, present in Timeline’s Skin Health line, targets both intrinsic (internal) and extrinsic (external) causes of skin aging to reduce fine lines, and protect from UV-related photodamage.

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Key takeaways

Reach your New Year (Re)New You goals by supporting your body’s natural process of cellular renewal.

Everyday strategies to stimulate this process include calorie restriction, fasting, polyphenol-rich foods, endurance and weight training exercises, and supplements like Mitopure.

Authors
Melissa Mitri, MS, RD

Melissa Mitri, MS, RD

Dietitian-Nutritionist, and Health Content Writer

Jen Scheinman, MS, RDN, CDN

Senior Manager of Nutrition Affairs

References
    1. Ji, S., Xiong, M., Chen, H. et al. Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases. Sig Transduct Target Ther 8, 116 (2023). https://doi.org/10.1038/s41392-023-01343-5 (https://doi.org/10.1038/s41392-023-01343-5)
  1. Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the Aging Skin. Adv Wound Care (New Rochelle). 2013;2(1):5-10. doi:10.1089/wound.2011.0356

  2. Anderson JE. Key concepts in muscle regeneration: muscle "cellular ecology" integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function. Eur J Appl Physiol. 2022;122(2):273-300. doi:10.1007/s00421-021-04865-4

    1. Haynes L. Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults. Front Aging. 2020;1:602108. Published 2020 Oct 15. doi:10.3389/fragi.2020.602108
  3. Azam S, Haque ME, Balakrishnan R, Kim IS, Choi DK. The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration. Front Cell Dev Biol. 2021;9:683459. Published 2021 Aug 13. doi:10.3389/fcell.2021.683459

  4. Everson CA, Henchen CJ, Szabo A, Hogg N. Cell injury and repair resulting from sleep loss and sleep recovery in laboratory rats. Sleep. 2014;37(12):1929-1940. Published 2014 Dec 1. doi:10.5665/sleep.4244

  5. Carapeto, Priscila Viana, and Cristina Aguayo-Mazzucato. “Effects of exercise on cellular and tissue aging.” Aging vol. 13,10 (2021): 14522-14543. doi:10.18632/aging.203051

  6. Johnstone SE, Baylin SB. Stress and the epigenetic landscape: a link to the pathobiology of human diseases?. Nat Rev Genet. 2010;11(11):806-812. doi:10.1038/nrg2881

  7. Rittié L, Fisher GJ. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med. 2015;5(1):a015370. Published 2015 Jan 5. doi:10.1101/cshperspect.a015370

  8. Flanagan EW, Most J, Mey JT, Redman LM. Calorie Restriction and Aging in Humans. Annu Rev Nutr. 2020;40:105-133. doi:10.1146/annurev-nutr-122319-034601

  9. Napoleão A, Fernandes L, Miranda C, Marum AP. Effects of Calorie Restriction on Health Span and Insulin Resistance: Classic Calorie Restriction Diet vs. Ketosis-Inducing Diet. Nutrients. 2021;13(4):1302. Published 2021 Apr 15. doi:10.3390/nu13041302

  10. Pak M, Bozkurt S, Pınarbaşı A, Öz Arslan D, Aksungar FB. Effects of Prolonged Intermittent Fasting Model on Energy Metabolism and Mitochondrial Functions in Neurons. Ann Neurosci. 2022;29(1):21-31. doi:10.1177/09727531211072303

  11. Buono R, Longo VD. When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die. Cell. 2019;178(5):1038-1040. doi:10.1016

  12. Zhang Q, Zhang C, Wang H, Ma Z, Liu D, Guan X, Liu Y, Fu Y, Cui M, Dong J. Intermittent Fasting versus Continuous Calorie Restriction: Which Is Better for Weight Loss? Nutrients. 2022; 14(9):1781. https://doi.org/10.3390/nu14091781

  13. Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Front Nutr. 2018;5:87. Published 2018 Sep 21. doi:10.3389/fnut.2018.00087

  14. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4

    Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633

  15. Werner CM, Hecksteden A, Morsch A, et al. Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. Eur Heart J. 2019;40(1):34-46. doi:10.1093/eurheartj/ehy585

    1. Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633

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Table of contents
Authors
Melissa Mitri, MS, RD

Dietitian-Nutritionist, and Health Content Writer

Jen Scheinman, MS, RDN, CDN

Senior Manager of Nutrition Affairs

Knowledge is power
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

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