Mitopure® is the only highly pure form of Urolithin A, clinically proven to activate mitophagy. Mitopure® (Urolithin A) is a powerful natural compound that has been extensively studied in both pre-clinical models and randomized, placebo-controlled, human trials for its potential to support mitochondrial health, cellular energy and enhance muscle strength*, as well as targeting visible signs of skin aging when applied topically.

User experiences suggest increased and sustained energy, reduced muscle fatigue during exercise, and faster recovery after physical activity, though these outcomes have not been confirmed in clinical studies. Reported effects tend to be cumulative and are typically noticed after 2–4 months.

While everyone may not physically feel the benefits, our clinical trials have shown that Mitopure® targets a key driver of aging, triggering the mitochondrial recycling process, called mitophagy, with sustained mitochondrial health benefits.

Mitopure® supports long-term mitochondrial health by activating mitophagy, the body's natural process for removing and replacing damaged mitochondria. By helping to restore this cleanup process, Mitopure® supports a healthier pool of mitochondria inside cells, enabling them to produce energy. Clinical studies have demonstrated improvements in cellular energy and muscle strength,* even without a change in exercise routine.

Creatine supports short-term energy production, helping to fuel muscles for short, explosive bursts of power. Taken alone, without strength training, creatine has minimal impact on muscle quality.

Developed by Timeline Longevity after over 18 years of research, Mitopure® is the only clinically proven Urolithin A supplement available on the market. Mitopure® (Urolithin A) has been evaluated in multiple human trials across a diverse population, demonstrating meaningful health outcomes and verified purity, stability, and bioavailability. It has been successfully notified to the FDA as a GRAS (Generally Recognized as Safe) ingredient and is NSF Contents Certified, unlike many generic alternatives, which may lack rigorous safety testing.